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Lamin B Receptor Polyclonal Antibody, FITC Conjugated

Product Specifications

Background

Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization. Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. The cleavage of lamins results in nuclear disregulation and cell death.

Synonyms

PHA; LMN2R; TDRD18; DHCR14B; Lamin-B receptor; Integral nuclear envelope inner membrane protein; LBR

Gene ID

3930

Swiss Prot

Q14739

Cellular Locus

Cytoplasm, Nucleus, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse

Immunogen

1-100/615

Target

Lamin B Receptor

Clonality

Polyclonal

Isotype

IgG

Conjugation

FITC

Source

KLH conjugated synthetic peptide derived from human Lamin B Receptor

Applications

WB, FCM

Purification

Purified by Protein A.

Excitation Emission

494nm/518nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.biossantibodies.com/datasheets/bs-5081R-FITC

Specificity

The immunogen for this product has partial sequence similarity to SEPT8 and SEPT2

Gene ID URL

3930

Predicted Cross Reactivity

Rat, Cow, Horse, Rabbit

Curated Selection

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