Rb2 p130 Polyclonal Antibody, FITC Conjugated
Product Specifications
Background
P130 is related both in structure and function to the retinoblastoma tumor suppressor protein and p107 (collectively known as pocket proteins) and is known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S phase of the cell cycle. Binding of p130 converts E2F transcription factors from transcriptional activators to transcriptional repressors.
Synonyms
130 kDa retinoblastoma associated protein; FLJ26459; p130; PRB 2; PRB2; Rb 2; Rb2; RBL2; RBR 2; RBR2; Retinoblastoma like 2; Retinoblastoma like protein 2; Retinoblastoma Related Gene.
Cellular Locus
Nucleus
Host
Rabbit
Immunogen
51-150/1139
Target
Rb2 p130
Clonality
Polyclonal
Isotype
IgG
Conjugation
FITC
Source
KLH conjugated synthetic peptide derived from human Rb2 p130
Applications
IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
494nm/518nm
Concentration
1µg/µl
Dilution
IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Horse, Rabbit
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