TDI-10229
TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10) . TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound[1][2].
Product Specifications
CAS Number
2810887-45-5
UNSPSC
12352005
Target
Adenylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tdi-10229.html
Purity
99.84
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1=C(C(C2=CC(Cl)=NC(N)=N2)=NN1C)CC3=CC=CC=C3
Molecular Formula
C16H16ClN5
Molecular Weight
313.78
References & Citations
[1]Balbach M, et al. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization [published online ahead of print, 2021 Aug 31]. Mol Hum Reprod. 2021; gaab054.|[2]Fushimi M, et al. Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10) . ACS Med Chem Lett. 2021;12 (8) :1283-1287. Published 2021 Jul 14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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