KEAP1 Polyclonal Antibody, AbBy Fluor™ 680 Conjugated
Product Specifications
Background
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Synonyms
Cytosolic inhibitor of Nrf2; INrf 2; INrf2; Keap 1; KEAP1; KEAP1_HUMAN; Kelch like ECH associated protein 1; Kelch like protein 19; Kelch-like ECH-associated protein 1; Kelch-like protein 19; KIAA0132; KLHL 19; KLHL19; MGC10630; MGC1114; MGC20887; MGC4407; MGC9454.
Gene ID
9817
Swiss Prot
Q14145
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
21-120/624
Target
KEAP1
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 680
Source
KLH conjugated synthetic peptide derived from human KEAP1
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
679nm/702nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
9817
Predicted Cross Reactivity
Dog, Cow, Pig, Rabbit
More Discoveries
Explore Other Products
Browse additional items from our catalog
486127 100 µL
MRPL43 (39S Ribosomal Protein L43, Mitochondrial, Mitochondrial Ribosomal Protein L43)
Sign In for Pricing
View Details MBS5827205 Inquire
9-(2,5-Di-O-benzoyl-2-C-beta-ethynyl-beta-D-ribofuranosyl)-6-chloropurine
Sign In for Pricing
View Details 
abx575233-01 96 Tests
Rabbit Matrix Metalloproteinase 9 (MMP9) ELISA Kit
Sign In for Pricing
View Details 
abx575233-02 5x 96 Tests
Rabbit Matrix Metalloproteinase 9 (MMP9) ELISA Kit
Sign In for Pricing
View Details 
abx575233-03 10x 96 Tests
Rabbit Matrix Metalloproteinase 9 (MMP9) ELISA Kit
Sign In for Pricing
View Details K4227602 1.0 µg DNA
Pdzrn4 sgRNA CRISPR Lentivector (Mouse) (Target 1)
Sign In for Pricing
View Details