KEAP1 Polyclonal Antibody, AbBy Fluor™ 647 Conjugated
Product Specifications
Background
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Synonyms
Cytosolic inhibitor of Nrf2; INrf 2; INrf2; Keap 1; KEAP1; KEAP1_HUMAN; Kelch like ECH associated protein 1; Kelch like protein 19; Kelch-like ECH-associated protein 1; Kelch-like protein 19; KIAA0132; KLHL 19; KLHL19; MGC10630; MGC1114; MGC20887; MGC4407; MGC9454.
Gene ID
9817
Swiss Prot
Q14145
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Immunogen
21-120/624
Target
KEAP1
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 647
Source
KLH conjugated synthetic peptide derived from human KEAP1
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/665nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
9817
Predicted Cross Reactivity
Dog, Cow, Pig, Rabbit
More Discoveries
Explore Other Products
Browse additional items from our catalog
NBP3-31854 1 Kit
Human Uroguanylin - Ready-To-Use ELISA Kit (Colorimetric)
Sign In for Pricing
View Details 
PA-RA-07760 100 µg
Polyclonal antibody-Canine Guanine nucleotide-binding protein G(
Sign In for Pricing
View Details 
K3791605 3x 1.0 µg
Krit1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
Sign In for Pricing
View Details 
MBS7163628 Inquire
Rabbit anti-Shigella flexneri YECA Polyclonal Antibody
Sign In for Pricing
View Details