CD45 Polyclonal Antibody, PE Conjugated
Product Specifications
Background
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity) . Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) .
Synonyms
Lca; RT7; CD45; L-CA; T200; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; Ptprc
Gene ID
24699
Swiss Prot
P04157
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
501-600/1273
Target
CD45
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE
Source
KLH conjugated synthetic peptide derived from rat CD45
Applications
WB, IF (IHC-P), IF (IHC-F)
Purification
Purified by Protein A.
Excitation Emission
496,564nm/578nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
24699
Predicted Cross Reactivity
Mouse, Rat
Curated Selection
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