Phospho-IRE1a (Ser 726) Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Synonyms
IRE1; IRE1P; IRE1a; hIRE1p; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; Ire1-alpha; ERN1
Gene ID
2081
Swiss Prot
O75460
Modification Site
Ser 726
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-IRE1a (Ser 726)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic phosphopeptide derived from human IRE1a around the phosphorylation site of Ser 726
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
2081
Predicted Cross Reactivity
Dog, Cow, Pig, Horse, Rabbit
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
NBP1-21513MFV450 0.1 mL
Mouse Monoclonal Dectin-1/CLEC7A Antibody (BD6) [mFluor Violet 450 SE]
Sign In for Pricing
View Details 
K1298308 1.0 µg DNA
MGAT2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
Sign In for Pricing
View Details