PHD1 Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.
Synonyms
Egl nine homolog 2; prolyl hydroxylase; EGLN 2; EGLN2; EIT 6; EIT6; H P4H 1; H PH1; HPH1; HPH 3; HPH3; P4H1; PHD 1; PHD1; EGL nine C.elegans homolog 2; EGLN2_HUMAN.
Gene ID
112398
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
321-407/407
Target
PHD1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human PHD1/prolyl hydroxylase
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
112398
Predicted Cross Reactivity
Human, Rat, Cow, Sheep
Curated Selection
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