PHD1 Polyclonal Antibody, AbBy Fluor™ 750 Conjugated
Product Specifications
Background
PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.
Synonyms
Egl nine homolog 2; prolyl hydroxylase; EGLN 2; EGLN2; EIT 6; EIT6; H P4H 1; H PH1; HPH1; HPH 3; HPH3; P4H1; PHD 1; PHD1; EGL nine C.elegans homolog 2; EGLN2_HUMAN.
Gene ID
112398
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
321-407/407
Target
PHD1
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 750
Source
KLH conjugated synthetic peptide derived from human PHD1/prolyl hydroxylase
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
749nm/775nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
112398
Predicted Cross Reactivity
Human, Rat, Cow, Sheep
More Discoveries
Explore Other Products
Browse additional items from our catalog
K4364705 3x 1.0 µg
Anxa1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
Sign In for Pricing
View Details 
50328114 3x 1.0 µg
Wdr4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
Sign In for Pricing
View Details 