PHD1 Polyclonal Antibody, APC-Cy5.5 Conjugated

Product Specifications

Background

PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.

Synonyms

Egl nine homolog 2; prolyl hydroxylase; EGLN 2; EGLN2; EIT 6; EIT6; H P4H 1; H PH1; HPH1; HPH 3; HPH3; P4H1; PHD 1; PHD1; EGL nine C.elegans homolog 2; EGLN2_HUMAN.

Gene ID

112398

Cellular Locus

Cytoplasm, Nucleus

Host

Rabbit

Cross Reactivity

Mouse

Immunogen

321-407/407

Target

PHD1

Clonality

Polyclonal

Isotype

IgG

Conjugation

APC-Cy5.5

Source

KLH conjugated synthetic peptide derived from human PHD1/prolyl hydroxylase

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

650nm/694nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

112398

Predicted Cross Reactivity

Human, Rat, Cow, Sheep

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP2-72427CL1 0.1 mL

Mouse Monoclonal BTLA/CD272 Antibody (OTI2E4) [CoraFluor 1]

Ask

View Details

NBP2-90543APC 0.1 mL

Rabbit Monoclonal Coagulation Factor II/Thrombin Antibody (318) [Allophycocyanin]

Ask

View Details

NBP2-90002AF488 0.1 mL

Rabbit Monoclonal IL-2 Antibody (011) [Alexa Fluor 488]

Ask

View Details

133453-ML550 100 µL

SLC26A3 (Chloride Anion Exchanger, Down-regulated in Adenoma, Protein DRA, Solute Carrier Family 26 Member 3, DRA) (MaxLight 550)

Ask

View Details

LY419243 100 µg

PAFAH1B2 (NM_002572) Human Over-expression Lysate

Ask

View Details

MBS6283437-01 0.2 mL

CD72, ID (CD72, B Cell differentiation antigen CD72, Lyb-2, CD72) (FITC)

Ask

View Details