OST-beta Polyclonal Antibody, Cy7 Conjugated
Product Specifications
Background
The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor) . This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.
Synonyms
Organic solute transporter beta (Ostbeta) ; Organic solute transporter subunit beta; Ostbeta; Ost beta; OSTB; OSTB_HUMAN.
Gene ID
123264
Swiss Prot
Q86UW2
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
57-128/128
Target
OST-beta
Clonality
Polyclonal
Isotype
IgG
Conjugation
Cy7
Source
Recombinant human OST-beta protein
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
743nm/767nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
123264
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