LRP5 Polyclonal Antibody, APC-Cy5.5 Conjugated

Product Specifications

Background

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

Synonyms

HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; VBCH2; Low-density lipoprotein receptor-related protein 5; LRP5

Gene ID

4041

Swiss Prot

O75197

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse

Immunogen

501-600/1615

Target

LRP5

Clonality

Polyclonal

Isotype

IgG

Conjugation

APC-Cy5.5

Source

KLH conjugated synthetic peptide derived from human LRP5

Applications

IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

650nm/694nm

Concentration

1µg/µl

Dilution

IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Unmodified

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This antibody will recognize LRP6 due to high sequence similarity.

Gene ID URL

4041

Predicted Cross Reactivity

Rat, Dog, Cow, Horse, Chicken, Rabbit

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

RC218846L4V 200 µL

BCKDHB (NM_000056) Human Tagged ORF Clone Lentiviral Particle

Ask

View Details

AMM17448VCF 100 µg

CD252 (TNFSF4) Mouse Monoclonal Antibody [Clone ID: LBI5D8]

Ask

View Details

mh40982 500 ng

LentimiRa-hsa-miR-675-5p Vector

Ask

View Details

MR224468 10 µg

Zfp786 (NM_177882) Mouse Tagged ORF Clone

Ask

View Details

bs-5813R-BF594-01 20 µL

PRODH Polyclonal Antibody, AbBy Fluor™ 594 Conjugated

Ask

View Details

bs-5813R-BF594-02 100 µL

PRODH Polyclonal Antibody, AbBy Fluor™ 594 Conjugated

Ask

View Details