Ro 46-8443
Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ETB (IC50: 34-69 nM) over ETA receptors (IC50: 6800 nM) [1][2].
Product Specifications
CAS Number
175556-12-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ro-46-8443.html
Purity
98.93
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC(C3=CC=C(OC)C=C3)=NC(OC[C@H](O)CO)=C2OC4=CC=CC=C4OC)=O
Molecular Formula
C31H35N3O8S
Molecular Weight
609.69
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Breu V, et al. In vitro characterisation of Ro 46-8443, the first non-peptide antagonist selective for the endothelin ETB receptor. FEBS Lett. 1996;383 (1-2) :37-41. |[2]Clozel M, et al. The role of ETB receptors in normotensive and hypertensive rats as revealed by the non-peptide selective ETB receptor antagonist Ro 46-8443. FEBS Lett. 1996;383 (1-2) :42-45.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ETA; ETB
Available Sizes
Frequently Asked Questions
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