Phospho-CBL (Tyr674) Polyclonal Antibody, FITC Conjugated
Product Specifications
Background
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
Synonyms
C CBL Tyr674; CBL2 Tyr674; CBL2 Y674; p-CBL2 Tyr674; p-CBL2 Y674; C CBL; Cas Br M murine ecotropic retroviral transforming sequence; Cas-Br-M murine ecotropic retroviral transforming sequence; Casitas B lineage lymphoma proto oncogene; Casitas B-lineage lymphoma proto-oncogene; CBL 2; cbl; CBL_HUMAN; CBL2; E3 ubiquitin protein ligase CBL; E3 ubiquitin-protein ligase CBL; Oncogene CBL2; Proto oncogene c CBL; Proto-oncogene c-CBL; RGD1561386; RING finger protein 55; RNF55; Signal transduction protein CBL.
Gene ID
867
Modification Site
Tyr674
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Others
Target
Phospho-CBL (Tyr674)
Clonality
Polyclonal
Isotype
IgG
Conjugation
FITC
Source
KLH conjugated synthetic phosphopeptide derived from human C CBL around the phosphorylation site of Tyr674
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
494nm/518nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
867
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS9000842 Inquire
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) PCS2 Polyclonal Antibody
Ask
View Details 
GA-E0294RT-01 48 Tests
Rat tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie-2) ELISA Kit
Ask
View Details 
GA-E0294RT-02 96 Tests
Rat tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie-2) ELISA Kit
Ask
View Details MR212898L3V 200 µL
1110032A03Rik (NM_023483) Mouse Tagged ORF Clone Lentiviral Particle
Ask
View Details