Phospho-HMGCR (Ser872) Polyclonal Antibody, PE-Cy7 Conjugated
Product Specifications
Background
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Synonyms
LDLCQ3; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; HMGCR; phospho HMGCR; p-HMGCR
Gene ID
3156
Swiss Prot
P04035
Modification Site
Ser872
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat, Rabbit
Target
Phospho-HMGCR (Ser872)
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE-Cy7
Source
KLH conjugated synthetic phosphopeptide derived from human HMGCR around the phosphorylation site of Ser872
Applications
WB, FCM
Purification
Purified by Protein A.
Excitation Emission
488nm/780nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
This phosphorylation site is homologous to that of Ser871 in Mouse and Rat.
Gene ID URL
3156
Predicted Cross Reactivity
Dog, Cow, Pig, Chicken
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