Phospho-HMGCR (Ser872) Polyclonal Antibody, PE-Cy5 Conjugated

Product Specifications

Background

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Synonyms

LDLCQ3; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; HMGCR; phospho HMGCR; p-HMGCR

Gene ID

3156

Swiss Prot

P04035

Modification Site

Ser872

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat, Rabbit

Target

Phospho-HMGCR (Ser872)

Clonality

Polyclonal

Isotype

IgG

Conjugation

PE-Cy5

Source

KLH conjugated synthetic phosphopeptide derived from human HMGCR around the phosphorylation site of Ser872

Applications

WB, FCM

Purification

Purified by Protein A.

Excitation Emission

488nm/670nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This phosphorylation site is homologous to that of Ser871 in Mouse and Rat.

Gene ID URL

3156

Predicted Cross Reactivity

Dog, Cow, Pig, Chicken

Curated Selection

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