Chlorphenoxamine

Chlorphenoxamine, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine shows anti-filovirus activity against both EBOV and Marburg virus (MARV)   with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease[1][2][3][4][5].

Product Specifications

CAS Number

[77-38-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Filovirus; Histamine Receptor; Parasite; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Chlorphenoxamine.html

Purity

99.20

Solubility

DMSO : ≥ 48 mg/mL

Smiles

CN(CCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)C)C

Molecular Formula

C18H22ClNO

Molecular Weight

303.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Ashraf A, et al. Novel RP-HPLC-DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances. BMC Chem. 2024;18 (1) :133. Published 2024 Jul 19.|[2]Ashraf A, et al. Smart green spectrophotometric estimation and content uniformity testing of chlorphenoxamine HCl and caffeine in bulk forms and combined pharmaceutical formulation. Sci Rep. 2025;15 (1) :9482. Published 2025 Mar 19.|[3]BAZEX A, et al. Trial treatment of urticaria with chlorphenoxamine. Clinique (Paris) . 1963 Jul-Aug;58:447-50.|[4]ULDALL PR, et al. Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial. Br Med J. 1961 Jun 10;1 (5240) :1649-52.|[5]Schafer A, et al. Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics. Antiviral Res. 2018 Sep;157:47-56.