RAE1 Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Mutations in Rae1 and Gle2 (Saccharomyces cerevisae homolog) genes have been shown to result in accumulation of poly (A) -containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Depletion of Rae1 from extracts or cells severely inhibits mitotic spindle assembly. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Synonyms
RAE-1; MIG 14; MIG14; Mnrp 41; Mnrp41; mRNA associated protein mrnp 41; mRNA binding protein 41 kD; mRNA export protein; MRNP 41; MRNP41; RAE 1; RAE1 RNA export 1 S.pombe homolog; RAE1 homolog; Rae1 protein homolog; RAE1 RNA export 1 homolog; RNA export 1; RNA export 1 homolog; Homolog of yeast Rae1 mRNA associated protein of 41 kDa. RAE1L_HUMAN
Gene ID
8480
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Immunogen
101-200/368
Target
RAE1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic peptide derived from human RAE1
Applications
ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
8480
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit
Curated Selection
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