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Phospho-VEGF receptor 2 (Tyr1059) Polyclonal Antibody, HRP Conjugated

Product Specifications

Background

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009].

Synonyms

VEGFR2Tyr1059; VEGFR2Y1059; p-VEGFR2Tyr1059; p-VEGFR2Y1059; CD309; CD309 antigen; Fetal liver kinase 1; FLK-1; FLK1; KDR; Kinase insert domain receptor a type III receptor tyrosine kinase; Kinase insert domain receptor; KRD1; Ly73; Protein tyrosine kinase receptor FLK1; Protein-tyrosine kinase receptor flk-1; Tyrosine kinase growth factor receptor; Vascular endothelial growth factor receptor 2; VEGFR 2; VEGFR; VEGFR-2; VEGFR2; VGFR2_HUMAN.

Gene ID

3791

Modification Site

Tyr1059

Cellular Locus

Cytoplasm, Nucleus, Secreted, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse, Others

Target

Phospho-VEGF receptor 2 (Tyr1059)

Clonality

Polyclonal

Isotype

IgG

Conjugation

HRP

Source

KLH conjugated synthetic phosphopeptide derived from human VEGF receptor 2 around the phosphorylation site of Tyr1059

Applications

WB, IHC-P, IHC-F

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

3791

Predicted Cross Reactivity

Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit

Curated Selection

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