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Phospho-TNK1 (Tyr277) Polyclonal Antibody

Product Specifications

Background

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

Synonyms

Non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1; TNK1

Gene ID

8711

Swiss Prot

Q13470

Modification Site

Tyr277

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Mouse

Target

Phospho-TNK1 (Tyr277)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

KLH conjugated synthetic phosphopeptide derived from human TNK1 around the phosphorylation site of Tyr277 [GR (p-Y) VM]

Applications

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Specificity

This phosphorylation site is homologous across the listed species.

Gene ID URL

8711

Predicted Cross Reactivity

Human, Rat, Dog, Pig, Horse, Rabbit, GuineaPig

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