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Phospho-Tuberin (Tyr1571) Polyclonal Antibody, AbBy Fluor™ 594 Conjugated

Product Specifications

Background

Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.

Synonyms

Tuberinphospho Y1571; Tuberin phospho Tyr1571; p-Tuberin Tyr1571; FLJ43106; LAM; OTTHUMP00000158940; OTTHUMP00000198394; OTTHUMP00000198395; TSC2; TSC2_HUMAN; TSC4; Tuberin; Tuberous sclerosis 2; Tuberous sclerosis 2 protein; Tuberous sclerosis 2 protein homolog.

Gene ID

7249

Modification Site

Tyr1571

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-Tuberin (Tyr1571)

Clonality

Polyclonal

Isotype

IgG

Conjugation

AbBy Fluor™ 594

Source

KLH conjugated synthetic phosphopeptide derived from human Tuberin around the phosphorylation site of Thr1571

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

590nm/617nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.biossantibodies.com/datasheets/bs-3443R-BF594

Gene ID URL

7249

Predicted Cross Reactivity

Mouse, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit

Curated Selection

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