N3PT
N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an Kd value of 22 nM (Apo-TK, transketolase lacking bound thiamine) [1].
Product Specifications
CAS Number
13860-66-7
Product Name Alternative
N3-pyridyl thiamine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Transketolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n3pt.html
Purity
98.63
Solubility
DMSO : 2.86 mg/mL (ultrasonic)
Smiles
CC1=C(CCO)SC=[N+]1CC2=CC=C(C)N=C2N.[H]Cl.[Cl-]
Molecular Formula
C13H19Cl2N3OS
Molecular Weight
336.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Allen A. Thomas, Josh Ballard, Bryan Bernat. Potent and Selective Thiamine Antagonists 
 That Inhibit Transketolase.|[2]Jeno Gyuris, May Han, Ronan C, N3-pyridyl-thiamine and its use in cancer treatments. Patent Numeber: WO2005094803 A2|[3]Thomas AA, De Meese J, Le Huerou Y, Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett. 2008 Jan 15;18 (2) :509-12.|[4]Thomas AA, et al. Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. Bioorg Med Chem Lett. 2008 Mar 15;18 (6) :2206-10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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