N3PT
N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an Kd value of 22 nM (Apo-TK, transketolase lacking bound thiamine) [1].
Product Specifications
CAS Number
13860-66-7
Product Name Alternative
N3-pyridyl thiamine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Transketolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n3pt.html
Purity
98.63
Solubility
DMSO : 2.86 mg/mL (ultrasonic)
Smiles
CC1=C(CCO)SC=[N+]1CC2=CC=C(C)N=C2N.[H]Cl.[Cl-]
Molecular Formula
C13H19Cl2N3OS
Molecular Weight
336.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Allen A. Thomas, Josh Ballard, Bryan Bernat. Potent and Selective Thiamine Antagonists 
 That Inhibit Transketolase.|[2]Jeno Gyuris, May Han, Ronan C, N3-pyridyl-thiamine and its use in cancer treatments. Patent Numeber: WO2005094803 A2|[3]Thomas AA, De Meese J, Le Huerou Y, Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett. 2008 Jan 15;18 (2) :509-12.|[4]Thomas AA, et al. Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. Bioorg Med Chem Lett. 2008 Mar 15;18 (6) :2206-10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC402065-100 1x 100 µL
IL3RA / CD123 (Acute Myeloid Leukemia Marker) (IL3RA/2065), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680210-100 1x 100 µL
Giardia lamblia (BB1.1E5), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 