N3PT

N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an Kd value of 22 nM (Apo-TK, transketolase lacking bound thiamine) [1].

Product Specifications

CAS Number

[13860-66-7]

Product Name Alternative

N3-pyridyl thiamine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Transketolase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n3pt.html

Purity

98.63

Solubility

DMSO : 2.86 mg/mL (ultrasonic)

Smiles

CC1=C(CCO)SC=[N+]1CC2=CC=C(C)N=C2N.[H]Cl.[Cl-]

Molecular Formula

C13H19Cl2N3OS

Molecular Weight

336.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Allen A. Thomas, Josh Ballard, Bryan Bernat. Potent and Selective Thiamine Antagonists  That Inhibit Transketolase.|[2]Jeno Gyuris, May Han, Ronan C, N3-pyridyl-thiamine and its use in cancer treatments. Patent Numeber: WO2005094803 A2|[3]Thomas AA, De Meese J, Le Huerou Y, Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett. 2008 Jan 15;18 (2) :509-12.|[4]Thomas AA, et al. Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. Bioorg Med Chem Lett. 2008 Mar 15;18 (6) :2206-10.