Phospho-Tyk2 (Tyr1054 + Tyr1055) Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq].
Synonyms
TYK2Tyr1054/1055; Tyk2phospho Y1054/1055; TYK2 phospho Tyr1054/1055; p-TYK2 Tyr1054/1055; JTK 1; JTK1; TYK 2; Non receptor tyrosine protein kinase 2; Non receptor tyrosine protein kinase TYK2; Protein Tyrosine Kinase 2; Tyrosine kinase 2; TYK2_HUMAN; Non-receptor tyrosine-protein kinase TYK2.
Gene ID
7297
Swiss Prot
P29597
Modification Site
Tyr1054 + Tyr1055
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-Tyk2 (Tyr1054 + Tyr1055)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic phosphopeptide derived from human Tyk2 around the phosphorylation site of Tyr1054/1055
Applications
IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
7297
Predicted Cross Reactivity
Dog
Curated Selection
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