Phospho-Stat2 (Tyr690) Polyclonal Antibody, AbBy Fluor™ 680 Conjugated

Product Specifications

Background

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Synonyms

P113; ISGF-3; STAT113; Signal transducer and activator of transcription 2; STAT2

Gene ID

6773

Swiss Prot

P52630

Modification Site

Tyr690

Cellular Locus

Cytoplasm, Nucleus

Host

Rabbit

Cross Reactivity

Mouse

Target

Phospho-Stat2 (Tyr690)

Clonality

Polyclonal

Isotype

IgG

Conjugation

AbBy Fluor™ 680

Source

KLH conjugated synthetic phosphopeptide derived from human Stat2 around the phosphorylation site of Tyr690

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

679nm/702nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Specificity

This phosphorylation site is homologous to that of Tyr689 in Mouse and Tyr690 in Rat.

Gene ID URL

6773

Predicted Cross Reactivity

Human, Rat, Dog, Horse

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MR207780L4 10 µg

Cacnb4 (NM_146123) Mouse Tagged Lenti ORF Clone

Ask

View Details

RC228087L4V 200 µL

C15orf40 (NM_001160114) Human Tagged ORF Clone Lentiviral Particle

Ask

View Details

ELI-08424b 96 Tests

Bovine EIF2S2 ELISA KIT

Ask

View Details

LS149233-20ug 20 µg

IL23 Receptor (IL23R) (NM_144701) Human Over-expression Lysate

Ask

View Details

SI206527A 1 Each

Rat Icam4 Pre-designed siRNA Set A

Ask

View Details

ABC-X3399 1 Vial

Xpress™ Human VIPR1 Over-expressing Stable Cell Line

Ask

View Details