Phospho-PLCG 2 (Tyr759) Polyclonal Antibody, PE-Cy7 Conjugated

Product Specifications

Background

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. [provided by RefSeq, Sep 2011].

Synonyms

PLC 2; PLC gamma 2; PLC IV; PLCG2; 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2; EC 3.1.4.11; Phosphoinositide phospholipase C; Phospholipase C gamma 2; Phospholipase C, gamma 2 phosphatidylinositol specic; PLCG2_HUMAN.

Gene ID

5336

Modification Site

Tyr759

Cellular Locus

Cytoplasm, Cell membrane, Extracellular matrix

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-PLCG 2 (Tyr759)

Clonality

Polyclonal

Isotype

IgG

Conjugation

PE-Cy7

Source

KLH conjugated synthetic phosphopeptide derived from human PLC gamma 2 around the phosphorylation site of Tyr759

Applications

Purification

Purified by Protein A.

Excitation Emission

488nm/780nm

Concentration

1µg/µl

Dilution

WB (1:300-5000)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

5336

Predicted Cross Reactivity

Mouse, Rat, Dog, Cow, Pig, Horse, Rabbit

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