Phospho-PERK (Thr980) Polyclonal Antibody, Cy5 Conjugated

Product Specifications

Background

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR) -induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) . Involved in control of mitochondrial morphology and function.

Synonyms

Pek; Perk; AI427929; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; Eif2ak3

Gene ID

13666

Swiss Prot

Q9Z2B5

Modification Site

Thr980

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

Phospho-PERK (Thr980)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Cy5

Source

KLH conjugated synthetic phosphopeptide derived from mouse PERK around the phosphorylation site of Thr980

Applications

WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

625,650nm/670nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

13666

Predicted Cross Reactivity

Dog, Cow, Pig, Rabbit

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

125424-ML750 100 µL

CSTF2 (Cleavage Stimulation Factor 64kD Subunit, CSTF 64kD Subunit, CF-1 64kD Subunit, CstF-64, Cleavage Stimulation Factor 2) (MaxLight 750) discontinued

Ask

View Details

NBP2-82076AF700 0.1 mL

Rabbit Polyclonal NK3R/TACR3/Neurokinin B Receptor Antibody [Alexa Fluor 700]

Ask

View Details

22060818-1 200 µg

Beta-2 Microglobulin Human

Ask

View Details

BS1392-01 50 µL

Cyclin B1 (I120) polyclonal antibody

Ask

View Details

BS1392-02 100 µL

Cyclin B1 (I120) polyclonal antibody

Ask

View Details

RK300261 200 Reactions

MIR3592 Rat qPCR Template Standard (MI0015473)

Ask

View Details