Phospho-Numb (Ser276) Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Synonyms
S171; C14orf41; c14_5527; Protein numb homolog; h-Numb; Protein S171; NUMB
Gene ID
8650
Swiss Prot
P49757
Modification Site
Ser276
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-Numb (Ser276)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic phosphopeptide derived from human Numb around the phosphorylation site of Ser276
Applications
WB, ELISA, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Specificity
This phosphorylation site is homologous to that of Ser276 in Mouse and Ser275 in Rat.
Gene ID URL
8650
Predicted Cross Reactivity
Dog, Cow, Sheep, Pig, Horse, Chicken, Rabbit
Available Sizes
Curated Selection
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