Phospho-NF2 (Ser518) Polyclonal Antibody, FITC Conjugated

Product Specifications

Background

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Synonyms

ACN; SCH; BANF; Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin; NF2

Gene ID

4771

Swiss Prot

P35240

Modification Site

Ser518

Cellular Locus

Cytoplasm, Nucleus, Cell membrane

Host

Rabbit

Cross Reactivity

Mouse, Rat

Target

Phospho-NF2 (Ser518)

Clonality

Polyclonal

Isotype

IgG

Conjugation

FITC

Source

KLH conjugated synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Ser518

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

494nm/518nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

4771

Predicted Cross Reactivity

Human, Dog, Cow, Pig, Horse, Chicken, Rabbit

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NB110-41486AF350 0.1 mL

Rabbit Polyclonal ATP13A2 Antibody [Alexa Fluor 350]

Ask

View Details

38600124 3x 1.0µg DNA

RBM15 CRISPRa sgRNA lentivector (set of three targets)(Mouse)

Ask

View Details

MBS7003794-01 0.05 mg

SMPD3 Antibody; FITC conjugated

Ask

View Details

MBS7003794-02 0.1 mg

SMPD3 Antibody; FITC conjugated

Ask

View Details

MBS7003794-03 5x 0.1 mg

SMPD3 Antibody; FITC conjugated

Ask

View Details

302849-ML650 100 µL

YY1AP1 (YY1-Associated Protein 1, Hepatocellular Carcinoma Susceptibility Protein, Hepatocellular Carcinoma-Associated Protein 2, YY1AP1, HCCA2, YY1AP) (MaxLight 650) discontinued

Ask

View Details