Phospho-NF2 (Ser518) Polyclonal Antibody, Cy5.5 Conjugated

Product Specifications

Background

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Synonyms

ACN; SCH; BANF; Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin; NF2

Gene ID

4771

Swiss Prot

P35240

Modification Site

Ser518

Cellular Locus

Cytoplasm, Nucleus, Cell membrane

Host

Rabbit

Cross Reactivity

Mouse, Rat

Target

Phospho-NF2 (Ser518)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Cy5.5

Source

KLH conjugated synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Ser518

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

675nm/694nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

4771

Predicted Cross Reactivity

Human, Dog, Cow, Pig, Horse, Chicken, Rabbit

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

E56G2968 100 µL

Hsp27 Rabbit Monoclonal Antibody

Ask

View Details

sc-72261 10 µM

Rsf-1 siRNA (h)

Ask

View Details

NHFF-1123-HX316 Each

Luciferase Expressing Monkey Primary Ovarian Microvascular Endothelial Cells

Ask

View Details

RN212426 10 µg

Olr1275 (NM_001000800) Rat Untagged Clone

Ask

View Details

MBS9460699-01 0.1 mL

C22orf32 Antibody HRP Conjugated

Ask

View Details

MBS9460699-02 5x 0.1 mL

C22orf32 Antibody HRP Conjugated

Ask

View Details