Phospho-MYPT1 (Thr853) Polyclonal Antibody, HRP Conjugated
Product Specifications
Background
Key regulator of protein phosphatase 1C (PPP1C) . Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.
Synonyms
MBS; M130; MYPT1; Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunit; PPP1R12A
Gene ID
4659
Swiss Prot
O14974
Modification Site
Thr853
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
Phospho-MYPT1 (Thr853)
Clonality
Polyclonal
Isotype
IgG
Conjugation
HRP
Source
KLH conjugated synthetic phosphopeptide derived from human around the phosphorylation site of Thr853
Applications
ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
This phosphorylation site is homologous to that of Thr852 in Mouse and Thr855 in Rat.
Gene ID URL
4659
Predicted Cross Reactivity
Rat, Dog, Cow, Horse, Chicken, Rabbit
Curated Selection
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