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Phospho-MEK1/2 (Ser218 + Ser222) Polyclonal Antibody, RBITC Conjugated

Product Specifications

Background

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Synonyms

MAP2K1phospho S218/S222; Dual specicity mitogen activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAP/Erk kinase 1; Map2K1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; MEKK1; Mitogen activated protein kinase kinase 1; MKK 1; MKK1; PRKMK 1; PRKMK1; Protein kinase mitogen activated kinase 1 MAP kinase kinase 1; Protein kinase mitogen activated kinase 1; Protein kinase mitogen activated, kinase 1.

Gene ID

56045605

Modification Site

Ser218 + Ser222

Cellular Locus

Cytoplasm, Nucleus, Cell membrane

Host

Rabbit

Cross Reactivity

Human

Target

Phospho-MEK1/2 (Ser218 + Ser222)

Clonality

Polyclonal

Isotype

IgG

Conjugation

RBITC

Source

KLH conjugated synthetic phosphopeptide derived from human MEK1 around the phosphorylation site of Ser218/222

Applications

WB

Purification

Purified by Protein A.

Excitation Emission

570nm/595nm

Concentration

1µg/µl

Dilution

WB (1:300-5000)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.biossantibodies.com/datasheets/bs-3270R-RBITC

Specificity

These phosphorylation sites are homologous to Ser222 + Ser226 in MEK2 and are the same across the listed species.

Gene ID URL

56045605

Predicted Cross Reactivity

Mouse, Rat, Dog, Cow, Pig, Chicken, Rabbit

Curated Selection

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