Phospho-MEF2A (Thr312) Polyclonal Antibody, Biotin Conjugated
Product Specifications
Background
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT] (4) TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
Synonyms
Mef2; ADCAD1; RSRFC4; RSRFC9; Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1; MEF2A
Gene ID
4205
Swiss Prot
Q02078
Modification Site
Thr312
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Mouse
Target
Phospho-MEF2A (Thr312)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Biotin
Source
KLH conjugated synthetic phosphopeptide derived from human MEF2A around the phosphorylation site of Thr312
Applications
WB, ELISA, IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
4205
Predicted Cross Reactivity
Human, Rat, Dog, Cow, Horse, Rabbit
Curated Selection
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