Phospho-Lyn (Tyr507) Polyclonal Antibody, APC Conjugated
Product Specifications
Background
Lyn (also known as p53/56 Lyn) is a membrane associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphorylate Tec on multiple residues. Lyn can also be regulated by IL2 and IL3.
Synonyms
Lyn phospho Y508; Lyn phospho Tyr508; p-Lyn Tyr508; Hck 2; JTK 8; JTK8; ONCOGENE LYN; Tyrosine protein kinase LYN; V yes 1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral v yes 1 related oncogene homolog; AA407514; EC 2.7.10.2; FLJ26625; LYN_HUMAN.
Gene ID
4067
Modification Site
Tyr508
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-Lyn (Tyr507)
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC
Source
KLH conjugated synthetic phosphopeptide derived from human Lyn around the phosphorylation site of Tyr508
Applications
WB, IF (IHC-P)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
4067
Predicted Cross Reactivity
Dog, Cow, Sheep, Pig, Horse, Chicken, Cat, Rabbit, Zebrafish, GuineaPig
Curated Selection
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