Phospho-LIMK1 (Thr508) + LIMK2 (Thr505) Polyclonal Antibody, PE-Cy5.5 Conjugated
Product Specifications
Background
LIMK1 is a protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. LIMK1 may be involved in brain development; it is highly expressed in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
Synonyms
LIMK1Thr508; EC 2.7.11.1; LIM domain kinase 1; LIM mot-containing protein kinase; LIMK; LIMK-1; LIMK2; LIMK-2; LIM domain kinase 2; LIMK1_HUMAN.
Gene ID
3984
Modification Site
Thr505
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Rat
Target
Phospho-LIMK1 (Thr508) + LIMK2 (Thr505)
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE-Cy5.5
Source
KLH conjugated synthetic phosphopeptide derived from human LIMK1 and LIMK2 around the phosphorylation site of Thr508 and Thr505
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
488nm/694nm
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
3984
Predicted Cross Reactivity
Human, Mouse, Dog, Cow, Pig, Horse, Chicken, Rabbit
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