Exatecan intermediate 10
Exatecan intermediate 10 is an intermediate in the synthesis of Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 of 2[1].2 μM (0[1].975 μg/mL) for use in cancer research[1].
Product Specifications
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/exatecan-intermediate-10.html
Purity
99.92
Solubility
10 mM in DMSO
Smiles
O=C1OCC(C(N2C(C3=NC4=CC(F)=C(C5=C4C([C@@H](CC5)NC(C)=O)=C3C2)C)=C6)=O)=C6[C@@]1(CC)O
Molecular Formula
C26H24FN3O5
Molecular Weight
477.48
Precautions
H302, H315, H319, H335
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins
Available Sizes
Frequently Asked Questions
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