Phospho-IRS1 (Ser636 + Ser639) Polyclonal Antibody, HRP Conjugated
Product Specifications
Background
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity) .
Synonyms
HIRS-1; Insulin receptor substrate 1; IRS-1; IRS1
Gene ID
3667
Swiss Prot
P35568
Modification Site
Ser636 + Ser639
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-IRS1 (Ser636 + Ser639)
Clonality
Polyclonal
Isotype
IgG
Conjugation
HRP
Source
KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Ser636/639 [PM (p-S) PK (p-S) VS]
Applications
IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Specificity
This phosphorylation site is homologous to Ser632 + ser635 in Mouse and Rat IRS1. This protein is known to be highly conserved in this sequences region, thus , this antibody may react with IRS2 when phosphorylated at Ser679 + Ser682 in Human , Ser675 + Ser678 in Mouse, and Ser676 +Ser679 in Rat based on homology.
Gene ID URL
3667
Predicted Cross Reactivity
Dog, Cow, Pig, Horse, Rabbit
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