Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Phospho-IRS1 (Ser1101) Polyclonal Antibody, AbBy Fluor™ 680 Conjugated

Product Specifications

Background

Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

Synonyms

P-IRS1; IRS1Ser1101; HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS-1; IRS 1; IRS1; OTTHUMP00000164234; IRS1_HUMAN.

Gene ID

3667

Modification Site

Ser1101

Cellular Locus

Cytoplasm, Nucleus, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

Phospho-IRS1 (Ser1101)

Clonality

Polyclonal

Isotype

IgG

Conjugation

AbBy Fluor™ 680

Source

KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Ser1101 [HS (p-S) ET]

Applications

WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

679nm/702nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.biossantibodies.com/datasheets/bs-3197R-BF680

Gene ID URL

3667

Predicted Cross Reactivity

Cow, Pig, Chicken, Rabbit, GuineaPig

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

RPUSD4 Antibody, FITC conjugated
MBS1498066-01 0.05 mg

RPUSD4 Antibody, FITC conjugated

Ask
View Details
RPUSD4 Antibody, FITC conjugated
MBS1498066-02 0.1 mg

RPUSD4 Antibody, FITC conjugated

Ask
View Details
RPUSD4 Antibody, FITC conjugated
MBS1498066-03 5x 0.1 mg

RPUSD4 Antibody, FITC conjugated

Ask
View Details
SAFB Recombinant Antibody, PE Conjugated
bsm-62719R-PE-TR 20 µL

SAFB Recombinant Antibody, PE Conjugated

Ask
View Details
CALCOCO1 Adenovirus (Mouse)
14923054 1.0 ml

CALCOCO1 Adenovirus (Mouse)

Ask
View Details
Recombinant Bacillus cereus Aspartyl/glutamyl-tRNA (Asn/Gln) amidotransferase subunit B
MBS1193682-01 0.02 mg (E-Coli)

Recombinant Bacillus cereus Aspartyl/glutamyl-tRNA (Asn/Gln) amidotransferase subunit B

Ask
View Details