Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Phospho-H2AX (Ser139) Polyclonal Antibody, RBITC Conjugated

Product Specifications

Background

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Synonyms

H2AX; H2A.X; H2A/X; Histone H2AX; Histone H2A.X; H2AFX

Gene ID

3014

Swiss Prot

P16104

Modification Site

Ser140

Cellular Locus

Nucleus

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

Phospho-H2AX (Ser139)

Clonality

Polyclonal

Isotype

IgG

Conjugation

RBITC

Source

KLH conjugated synthetic phosphopeptide derived from human Histone H2AX around the phosphorylation site of Ser140

Applications

WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

570nm/595nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.biossantibodies.com/datasheets/bs-3185R-RBITC

Specificity

This phosphorylation site is homologous to that of Ser140 in Mouse and Rat.

Gene ID URL

3014

Predicted Cross Reactivity

Dog, Cow, Pig, Horse, Rabbit

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

PSMB9 (C-term) Rabbit Polyclonal Antibody
AP18163PU-N 400 µL

PSMB9 (C-term) Rabbit Polyclonal Antibody

Ask
View Details
Glaucocalyxin A diacetate
MBS5788346 Inquire

Glaucocalyxin A diacetate

Ask
View Details
MYO1F Peptide
DF2210-BP 1 mg

MYO1F Peptide

Ask
View Details
OXGR1 Antibody - C-terminal region
OAAB17838-400UL 400 µL

OXGR1 Antibody - C-terminal region

Ask
View Details
DFNB65 Protein Lysate (Human) with C-Ha Tag
18114031 100 μg

DFNB65 Protein Lysate (Human) with C-Ha Tag

Ask
View Details
BMP7 Rabbit Polyclonal Antibody
AP31724PU-N 100 µg

BMP7 Rabbit Polyclonal Antibody

Ask
View Details