Phospho-Gab1 (Tyr627) Polyclonal Antibody
Product Specifications
Background
Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c Met), and epidermal growth factor receptor (EGF), as well as in response to cell cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3 kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.
Synonyms
GAB1 (phospho Y627) ; Gab1 (Phospho-Tyr627) ; p-Gab1 (Tyr627) ; GAB1_HUMAN; GRB2-associated-binding protein 1; GAB1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1
Gene ID
2549
Swiss Prot
Q13480
Modification Site
Tyr627
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Mouse, Rat
Target
Phospho-Gab1 (Tyr627)
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated Synthesised phosphopeptide derived from human Gab1 around the phosphorylation site of Tyr627
Applications
WB
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
2549
Predicted Cross Reactivity
Human, Dog, Cow, Pig, Horse, Chicken
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