Phospho-GSK-3 Beta (Thr390) Polyclonal Antibody, PE Conjugated

Product Specifications

Background

Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. GSK3 has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control and oncogenesis. Two isoforms, alpha (GSK3A; OMIM 606784) and beta, show a high degree of amino acid homology within their catalytic domains. GSK3B is involved in energy metabolism, neuronal cell development and body pattern formation.

Synonyms

GSK3B (Thr390) ; GSK3B (T390) ; p-GSK-3 Beta (Thr390) ; p-GSK-3 beta (T390) ; Glycogen synthase kinase 3 beta; GSK 3 beta; GSK 3B; GSK3B; GSK3B protein; GSK3beta isoform; GSK3 beta; Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B_HUMAN.

Gene ID

2932

Modification Site

Thr390

Cellular Locus

Cytoplasm, Nucleus, Cell membrane

Host

Rabbit

Cross Reactivity

Human, Rat

Target

Phospho-GSK-3 Beta (Thr390)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Source

KLH conjugated Synthesised phosphopeptide derived from human GSK-3 Beta around the phosphorylation site of Thr390

Applications

WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

496,564nm/578nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

2932

Predicted Cross Reactivity

Dog, Pig, Chicken, Rabbit, GuineaPig

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