Phospho-GSK-3 Beta (Thr390) Polyclonal Antibody, FITC Conjugated
Product Specifications
Background
Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase. GSK3 has been implicated in fundamental cell processes such as cell fate determination, metabolism, transcriptional control and oncogenesis. Two isoforms, alpha (GSK3A; OMIM 606784) and beta, show a high degree of amino acid homology within their catalytic domains. GSK3B is involved in energy metabolism, neuronal cell development and body pattern formation.
Synonyms
GSK3B (Thr390) ; GSK3B (T390) ; p-GSK-3 Beta (Thr390) ; p-GSK-3 beta (T390) ; Glycogen synthase kinase 3 beta; GSK 3 beta; GSK 3B; GSK3B; GSK3B protein; GSK3beta isoform; GSK3 beta; Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B_HUMAN.
Gene ID
2932
Modification Site
Thr390
Cellular Locus
Cytoplasm, Nucleus, Cell membrane
Host
Rabbit
Cross Reactivity
Human, Rat
Target
Phospho-GSK-3 Beta (Thr390)
Clonality
Polyclonal
Isotype
IgG
Conjugation
FITC
Source
KLH conjugated Synthesised phosphopeptide derived from human GSK-3 Beta around the phosphorylation site of Thr390
Applications
WB, FCM, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
494nm/518nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
2932
Predicted Cross Reactivity
Dog, Pig, Chicken, Rabbit, GuineaPig
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