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Phospho-BMX (Tyr40) Polyclonal Antibody, APC Conjugated

Product Specifications

Background

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009].

Synonyms

BMX phospho Y40; BMX phospho Try40; BMX p-Y40; BMX p-Try40; p-BMX phospho Y40; BMX/ETK Tyr40; p-ETK Tyr40; Protein tyrosine kinase BMX; PSCTK 2; PSCTK 3; PSCTK2; PSCTK3; Bone marrow tyrosine kinase gene in chromosome X protein; BMX non receptor tyrosine kinase; Cytoplasmic tyrosine protein kinase BMX; Epithelial and endothelial tyrosine kinase; BMX_HUMAN; Cytoplasmic tyrosine-protein kinase BMX; ETK; NTK38; Protein tyrosine kinase BMX; Etk; Etk/Bmx; Tyro8.

Gene ID

660

Modification Site

Tyr40

Cellular Locus

Cytoplasm

Host

Rabbit

Cross Reactivity

Rat

Target

Phospho-BMX (Tyr40)

Clonality

Polyclonal

Isotype

IgG

Conjugation

APC

Source

KLH conjugated synthetic phosphopeptide derived from human ETK around the phosphorylation site of Tyr40

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

650nm/660nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

660

Predicted Cross Reactivity

Human, Mouse, Dog, Cow, Pig, Horse, Rabbit

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