Phospho-Cyclin E1 (Thr77) Polyclonal Antibody, AbBy Fluor™ 647 Conjugated
Product Specifications
Background
Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Synonyms
CCNE 1; CCNE; CCNE1; Cyclin E1 antibody Cyclin Es; Cyclin Et; CyclinE; G1/S specic cyclin E; CCNE1_HUMAN.
Gene ID
898
Modification Site
Thr77
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-Cyclin E1 (Thr77)
Clonality
Polyclonal
Isotype
IgG
Conjugation
AbBy Fluor™ 647
Source
KLH conjugated synthetic phosphopeptide derived from human Cyclin E around the phosphorylation site of Thr77
Applications
WB, FCM, IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/665nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
898
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
PT_71847-01 5 µg
Tyr-3/Trp-5 Monooxygenase Activation Protein Beta Human Recombinant (YWHAB Human)
Ask
View Details 
PT_71847-02 25 µg
Tyr-3/Trp-5 Monooxygenase Activation Protein Beta Human Recombinant (YWHAB Human)
Ask
View Details 
PT_71847-03 1 mg
Tyr-3/Trp-5 Monooxygenase Activation Protein Beta Human Recombinant (YWHAB Human)
Ask
View Details 