Phospho-Cyclin E1 (Thr77) Polyclonal Antibody, APC Conjugated
Product Specifications
Background
Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Synonyms
CCNE 1; CCNE; CCNE1; Cyclin E1 antibody Cyclin Es; Cyclin Et; CyclinE; G1/S specic cyclin E; CCNE1_HUMAN.
Gene ID
898
Modification Site
Thr77
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-Cyclin E1 (Thr77)
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC
Source
KLH conjugated synthetic phosphopeptide derived from human Cyclin E around the phosphorylation site of Thr77
Applications
WB, FCM, IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/660nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
898
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit
Curated Selection
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