Phospho-CRK (Tyr221) Polyclonal Antibody, PE Conjugated
Product Specifications
Background
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Synonyms
Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK
Gene ID
1398
Modification Site
Tyr221
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Others
Target
Phospho-CRK (Tyr221)
Clonality
Polyclonal
Isotype
IgG
Conjugation
PE
Source
KLH conjugated synthetic phosphopeptide derived from human Crk p38 around the phosphorylation site of Tyr221 [GP (p-Y) AQ]
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
496,564nm/578nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
1398
Predicted Cross Reactivity
Human, Mouse, Rat, Dog, Horse, Chicken, Rabbit
Curated Selection
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