Phospho-CRK (Tyr221) Polyclonal Antibody, AbBy Fluor™ 405 Conjugated

Product Specifications

Background

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Synonyms

Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK

Gene ID

1398

Modification Site

Tyr221

Cellular Locus

Cytoplasm, Cell membrane

Host

Rabbit

Cross Reactivity

Others

Target

Phospho-CRK (Tyr221)

Clonality

Polyclonal

Isotype

IgG

Conjugation

AbBy Fluor™ 405

Source

KLH conjugated synthetic phosphopeptide derived from human Crk p38 around the phosphorylation site of Tyr221 [GP (p-Y) AQ]

Applications

WB, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Excitation Emission

401nm/421nm

Concentration

1µg/µl

Dilution

WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Gene ID URL

1398

Predicted Cross Reactivity

Human, Mouse, Rat, Dog, Horse, Chicken, Rabbit

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

RD-SIAE-Hu-01 96 Tests

Human Sialic Acid Acetylesterase (SIAE) ELISA Kit

Ask

View Details

RD-SIAE-Hu-02 48 Tests

Human Sialic Acid Acetylesterase (SIAE) ELISA Kit

Ask

View Details

50745164 1.0 µg

Zc3h3 AAV siRNA Pooled Vector

Ask

View Details

52935111 3x 1.0 µg

ARCN2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

Ask

View Details

MBS1180595-01 0.02 mg (E-Coli)

Recombinant Bifidobacterium longum subsp. infantis UPF0286 protein Blon_0311/BLIJ_0316 (Blon_0311, BLIJ_0316)

Ask

View Details

MBS1180595-02 0.1 mg (E-Coli)

Recombinant Bifidobacterium longum subsp. infantis UPF0286 protein Blon_0311/BLIJ_0316 (Blon_0311, BLIJ_0316)

Ask

View Details