Phospho-Cofilin (Ser3) Polyclonal Antibody

Product Specifications

Background

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.

Synonyms

CFL; cofilin; HEL-S-15; Cofilin-1; 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform; CFL1

Gene ID

1072

Swiss Prot

P23528

Modification Site

Ser3

Cellular Locus

Cytoplasm, Nucleus

Host

Rabbit

Cross Reactivity

Mouse, Rat

Target

Phospho-Cofilin (Ser3)

Clonality

Polyclonal

Isotype

IgG

Conjugation

Unconjugated

Source

KLH conjugated synthetic phosphopeptide derived from human Cofilin around the phosphorylation site of Ser3

Applications

WB, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

Buffer

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Modification

Phosphorylation

Storage Conditions

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Specificity

This phosphorylation site is homologous in the listed cross reactive species at the specified location.

Gene ID URL

1072

Predicted Cross Reactivity

Human, Cow, Sheep, Pig, Horse

Available Sizes

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