Phospho-CENPA (Ser7) Polyclonal Antibody, APC-Cy5.5 Conjugated
Product Specifications
Background
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4) 2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Synonyms
CENP A; CENP-A; Centromere autoantigen A; Centromere protein A 17kDa; centromere protein A; centromeric protein A; Histone H3 like centromeric protein A.
Gene ID
1058
Modification Site
Ser7
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Target
Phospho-CENPA (Ser7)
Clonality
Polyclonal
Isotype
IgG
Conjugation
APC-Cy5.5
Source
KLH conjugated synthetic phosphopeptide derived from human CENP-A around the phosphorylation site of Ser7 [RR (p-S) RK]
Applications
WB, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Excitation Emission
650nm/694nm
Concentration
1µg/µl
Dilution
WB (1:300-5000), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
1058
Predicted Cross Reactivity
Rabbit
Curated Selection
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